Future perspective

Our aim is to collect more snapshots at highest possible resolution in order to provide a most complete picture of fundamental co-translational events. In the future we will, thus, concentrate our efforts on four topics: First, we plan to provide a complete molecular model of the 80S ribosome serving as the basis for a molecular understanding of cotranslational processes in eukaryotes. Second, we will look at different types of nascent polypeptide chains to address questions regarding translational stalling, regulation and secondary structure formation. Third, we will visualize cotranslationally acting chaperons on the active ribosome in order to understand the first steps of protein folding. Fourth, based on our understanding of the ribosome-bound protein-conducting channel we will expand our studies on nascent membrane protein insertion, processing and assembly.