Scientific Papers

  • 2011

  • Jarasch, A., Dziuk, P., Becker, T., Armache, J.P., Hauser,A., Wilson, D.N., and Beckmann, R. (in press)

    The DARC site: a database of aligned ribosomal complexes

    Nucleic Acids Research, 2011, 1–6

  • Wollmann, P., Cui, S., Viswanathan, R., Berninghausen, O., Wells, M.N., Moldt, M., Witte, G., Butryn, A., Wendler, P., Beckmann, R., Auble, D.T., and Hopfner, K.P. (2011).

    Structure and Mechanism of the Swi2/Snf2 Remodeller Mot1 in Complex with Its Substrate Tbp.

    Nature 475, 403-407.

  • Wilson, D.N., Bhushan, S., Becker, T., and Beckmann, R. (2011).

    Nascent polypeptide chains within the ribosomal tunnel analyzed by Cryo-EM.
    In: Eds. Rodnina, M, Wintermeyer, W, and Green, R
    Ribosomes: Structure, Function and Dynamics.(Springer-Verlag, Wien).

  • Frauenfeld, J., Gumbart, J., Sluis, E.O., Funes, S., Gartmann, M., Beatrix, B., Mielke, T., Berninghausen, O., Becker, T., Schulten, K., and Beckmann, R. (2011).

    Cryo-EM Structure of the Ribosome-Sec YE Complex in the Membrane Environment.

    Nat Struct Mol Biol 18, 614-621.

  • Wilson, D.N., and Beckmann, R. (2011).

    The Ribosomal Tunnel as a Functional Environment for Nascent Polypeptide Folding and Translational Stalling.

    Curr Opin Struct Biol 21, 274-282.

  • Braig, D., Mircheva, M., Sachelaru, I., van der Sluis, E.O., Sturm, L., Beckmann, R., and Koch, H.G. (2011).

    Signal Sequence-Independent SRP-SR Complex Formation at the Membrane Suggests an Alternative Targeting Pathway within the SRP Cycle.

    Mol Biol Cell 22, 2309-2323.

  • Becker, T., Armache, J.P., Jarasch, A., Anger, A.M., Villa, E., Sieber, H., Motaal, B.A., Mielke, T., Berninghausen, O., and Beckmann, R. (2011).

    Structure of the No-Go mRNA Decay Complex Dom34-Hbs1 Bound to a Stalled 80s Ribosome.

    Nat Struct Mol Biol 18, 715-720.

  • Marquez, V., Frohlich, T., Armache, J.P., Sohmen, D., Donhofer, A., Mikolajka, A., Berninghausen, O., Thomm, M., Beckmann, R., Arnold, G.J., and Wilson, D.N. (2011).

    Proteomic Characterization of Archaeal Ribosomes Reveals the Presence of Novel Archaeal-Specific Ribosomal Proteins.

    J Mol Biol 405, 1215-1232.

  • Bhushan, S., Hoffmann, T., Seidelt, B., Frauenfeld, J., Mielke, T., Berninghausen, O., Wilson, D.N., and Beckmann, R. (2011).

    SecM-Stalled Ribosomes Adopt an Altered Geometry at the Peptidyl Transferase Center.

    PLoS Biol 9, e1000581.

  • 2010

  • Armache, J.P., Jarasch, A., Anger, A.M., Villa, E., Becker, T., Bhushan, S., Jossinet, F., Habeck, M., Dindar, G., Franckenberg, S., Marquez, V., Mielke, T., Thomm, M., Berninghausen, O., Beatrix, B., Soding, J., Westhof, E., Wilson, D.N., and Beckmann, R. (2010a).

    Localization of Eukaryote-Specific Ribosomal Proteins in a 5.5Å Cryo-EM Map of the 80S Eukaryotic Ribosome.

    Proc Natl Acad Sci U S A 107, 19754-19759.

  • Armache, J.P., Jarasch, A., Anger, A.M., Villa, E., Becker, T., Bhushan, S., Jossinet, F., Habeck, M., Dindar, G., Franckenberg, S., Marquez, V., Mielke, T., Thomm, M., Berninghausen, O., Beatrix, B., Soding, J., Westhof, E., Wilson, D.N., and Beckmann, R. (2010b).

    Cryo-EM Structure and rRNA Model of a Translating Eukaryotic 80S Ribosome at 5.5Å Resolution.

    Proc Natl Acad Sci U S A 107, 19748-19753.

  • Bhushan, S., Meyer, H., Starosta, A.L., Becker, T., Mielke, T., Berninghausen, O., Sattler, M., Wilson, D.N., and Beckmann, R. (2010a).

    Structural Basis for Translational Stalling by Human Cytomegalovirus and Fungal Arginine Attenuator Peptide.

    Mol Cell 40, 138-146.

  • Bhushan, S., Gartmann, M., Halic, M., Armache, J.P., Jarasch, A., Mielke, T., Berninghausen, O., Wilson, D.N., and Beckmann, R. (2010b).

    Alpha-Helical Nascent Polypeptide Chains Visualized within Distinct Regions of the Ribosomal Exit Tunnel.

    Nat Struct Mol Biol 17, 313-317.

  • Pech, M., Spreter, T., Beckmann, R., and Beatrix, B. (2010).

    Dual Binding Mode of the Nascent Polypeptide-Associated Complex Reveals a Novel Universal Adapter Site on the Ribosome.

    J Biol Chem 285, 19679-19687.

  • Gartmann, M., Blau, M., Armache, J.P., Mielke, T., Topf, M., and Beckmann, R. (2010).

    Mechanism of eIF6-Mediated Inhibition of Ribosomal Subunit Joining.

    J Biol Chem 285, 14848-14851.

  • Liu C, Young AL, Starling-Windhof A, Bracher A, Saschenbrecker S, Rao BV, Rao KV, Berninghausen O, Mielke T, Hartl FU, Beckmann R, Hayer-Hartl M. (2010).

    Coupled chaperone action in folding and assembly of hexadecameric Rubisco.

    Nature. 463(7278):197-202.

  • 2009

  • Seidelt, B., Innis, C.A., Wilson, D.N., Gartmann, M., Armache, J.P., Villa, E., Trabuco, L.G., Becker, T., Mielke, T., Schulten, K., Steitz, T.A., and Beckmann, R. (2009).

    Structural Insight into Nascent Polypeptide Chain-Mediated Translational Stalling.

    Science 326, 1412-1415.

  • Becker, T., Bhushan, S., Jarasch, A., Armache, J.P., Funes, S., Jossinet, F., Gumbart, J., Mielke, T., Berninghausen, O., Schulten, K., Westhof, E., Gilmore, R., Mandon, E.C., and Beckmann, R. (2009).

    Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome.

    Science 326, 1369-1373.

  • 2008

  • Kusser, A.G., Bertero, M.G., Naji S., Becker, T., Thomm, M., Beckmann, R., Cramer, P. (2008).

    Structure of an archaeal RNA polymerase.

    J Mol Biol. 376, 303-307.

  • 2007

  • Kuhn, C.D., Geiger, S.R., Baumli, S., Gartmann, M., Gerber, J., Jennebach, S., Mielke, T., Tschochner, H., Beckmann, R., Cramer, P. (2007).

    Functional architecture of RNA polynerase I.

    Cell 131, 1260-1272.

  • 2006

  • Halic, M., Blau, M., Becker, T., Mielke, T., Pool, M.R., Wild, K., Sinning, I., and Beckmann, R. (2006b).

    Following the Signal Sequence from Ribosomal Tunnel Exit to Signal Recognition Particle.

    Nature 444, 507-511.

  • Halic, M., Gartmann, M., Schlenker, O., Mielke, T., Pool, M.R., Sinning, I., and Beckmann, R. (2006a).

    Signal Recognition Particle Receptor Exposes the Ribosomal Translocon Binding Site.

    Science 312, 745-747.

  • Andersen, C.B., Becker, T., Blau, M., Anand, M., Halic, M., Balar, B., Mielke, T., Boesen, T., Pedersen, J.S., Spahn, C.M., Kinzy, T.G., Andersen, G.R., and Beckmann, R. (2006).

    Structure of eEF3 and the Mechanism of Transfer Rna Release from the E-Site.

    Nature 443, 663-668.

  • 2005

  • Blau, M., Mullapudi, S., Becker, T., Dudek, J., Zimmermann, R., Penczek,P. A., Beckmann R.(2005)

    ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane.

    Nat. Struct. Mol. Biol., 12, 1015-1016.

  • Halic, M., Becker, T., Frank, J., Spahn, C.M., and Beckmann, R. (2005).

    Localization and Dynamic Behavior of Ribosomal Protein L30e.

    Nat Struct Mol Biol 12, 467-468.

  • Beckmann, R. (2005)

    Cryo-EM: single particle reconstruction,

    In: Ganten et al. (Ed.).
    The Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine

    Springer-Verlag, Berlin-Heidelberg, 

  • Halic, M., and Beckmann, R. (2005).

    The Signal Recognition Particle and Its Interactions During Protein Targeting.

    Curr Opin Struct Biol 15, 116-125.

  • 2004

  • Mullapudi, S., Pullan, L., Bishop, O.T., Khalil, H., Stoops, J.K., Beckmann, R., Kloetzel, P.M., Kruger, E., and Penczek, P.A. (2004).

    Rearrangement of the 16S Precursor Subunits Is Essential for the Formation of the Active 20S Proteasome.

    Biophys J 87, 4098-4105.

  • Wild, K., Halic, M., Sinning, I., and Beckmann, R. (2004).

    SRP Meets the Ribosome.

    Nat Struct Mol Biol 11, 1049-1053.

  • Halic, M., Becker, T., Pool, M.R., Spahn, C.M., Grassucci, R.A., Frank, J., and Beckmann, R. (2004).

    Structure of the Signal Recognition Particle Interacting with the Elongation-Arrested Ribosome.

    Nature 427, 808-814.

  • Spahn, C.M., Gomez-Lorenzo, M.G., Grassucci, R.A., Jorgensen, R., Andersen, G.R., Beckmann, R., Penczek, P.A., Ballesta, J.P., and Frank, J. (2004).

    Domain Movements of Elongation Factor eEF2 and the Eukaryotic 80S Ribosome Facilitate tRNA Translocation.

    Embo J 23, 1008-1019.

  • 2003

  • Opalka, N., Beckmann, R., Boisset, N., Simon, M.N., Russel, M., and Darst, S.A. (2003).

    Structure of the Filamentous Phage pIV Multimer by Cryo-Electron Microscopy.

    J Mol Biol 325, 461-470.

  • 2002

  • R. Beckmann(2002).

    Kalt erwischt: 3D-Momentaufnahmen der Proteintranslokation durch Kryo-Elektronenmikroskopie.

    Nachr. Chem., 2, 136-141.

  • 2001

  • R. Beckmann, C.M.T. Spahn, J. Frank and G. Blobel (2001).

    The active 80S ribosome-Sec61 complex, in: The Ribosome, Symposia on Quantitative Biology.

    Cold Spring Harbor Lab Press, Vol LXVI, 543-554.

  • Spahn, C.M., Beckmann, R., Eswar, N., Penczek, P.A., Sali, A., Blobel, G., and Frank, J. (2001).

    Structure of the 80S Ribosome from Saccharomyces cerevisiae-tRNA-Ribosome and Subunit-Subunit Interactions.

    Cell 107, 373-386.

  • Beckmann, R., Spahn, C.M., Frank, J., and Blobel, G. (2001a).

    The Active 80S Ribosome-Sec61 Complex.

    Cold Spring Harb Symp Quant Biol 66, 543-554.

  • Beckmann, R., Spahn, C.M., Eswar, N., Helmers, J., Penczek, P.A., Sali, A., Frank, J., and Blobel, G. (2001b).

    Architecture of the Protein-Conducting Channel Associated with the Translating 80S Ribosome.

    Cell 107, 361-372.

  • 2000

  • Groft, C.M., Beckmann, R., Sali, A., and Burley, S.K. (2000).

    Crystal Structures of Ribosome Anti-Association Factor IF6.

    Nat Struct Biol 7, 1156-1164.

  • Before 2000

  • Beckmann, R., Bubeck, D., Grassucci, R., Penczek, P., Verschoor, A., Blobel, G., and Frank, J. (1997).

    Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex.

    Science 278, 2123-2126.

  • Draguhn, A., Börner, G., Beckmann, R., Buchner, K., Heinemann, U. and Hucho, F. (1997).

    Large-conductance cation channels in the envelope of nuclei from rat cerebral cortex.

    J. Mem. Biol., 158, 159-166,

  • Beckmann, R., Lindschau, C., Haller, H., and Buchner, K. (1995).

    Bradykinin Induces Rise of Free Calcium in Nuclei of Neuroblastoma X Glioma Hybrid Ng 108-15 Cells.

    J Neurosci Res 40, 571-578.

  • Beckmann, R., Lindschau, C., Haller, H., Hucho, F., and Buchner, K. (1994).

    Differential Nuclear Localization of Protein Kinase C Isoforms in Neuroblastoma X Glioma Hybrid Cells.

    Eur J Biochem 222, 335-343.

  • Beckmann, R., Buchner, K., Jungblut, P.R., Eckerskorn, C., Weise, C., Hilbert, R., and Hucho, F. (1992).

    Nuclear Substrates of Protein Kinase C.

    Eur J Biochem 210, 45-51.

  • Otto, H., Buchner, K., Beckmann, R., Hilbert, R., and Hucho, F. (1992).

    GTP-Binding Proteins in Bovine Brain Nuclear Membranes.

    Neurochem Int 21, 409-414.

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